Linear 1 3-diarylpropanoids
Medchemexpress LLC 4'-Methoxychalcone | 959-23-9 | 99.8% | 5 G
4'-Methoxychalcone regulates adipocyte differentiation through PPARγ activation. It also modulates the expression and secretion of various adipokines in adipose tissue that are involved in insulin sensitivity. This product is intended for research use only.
- Regulates adipocyte differentiation via PPARγ activation
- Modulates adipokine expression and secretion involved in insulin sensitivity
- Increases mRNA expression of adipogenic genes during differentiation
- Reduces upregulated mRNA expression of IL-6, PAI-1, and MCP-1
- Causes an increase in PPARγ expression during differentiation
- Exhibits antiproliferative activity and cytotoxicity against various human cell lines
- Targets PPARγ
- Derived from Piperaceae Piper nigrum Linn.
- Classified as flavonoids, chalcones
Medchemexpress LLC Isodecyl diphenyl phosphate | 29761-21-5 | MFCD00072254 | 99.0% | 390.45 | C22H31O4P | 10mg
Isodecyl diphenyl phosphate (IDPP) is a flame retardant IDPP has an ability to induce DNA damage and exertes S phase cell ratio-reducing effects in A549 cells[1]
Medchemexpress LLC Isodecyl diphenyl phosphate | 29761-21-5 | MFCD00072254 | 390.45 g/mol | C22H31O4P | 25mg
Isodecyl diphenyl phosphate (IDPP) is a flame retardant IDPP has an ability to induce DNA damage and exertes S phase cell ratio-reducing effects in A549 cells[1]
Medchemexpress LLC AKT-IN-23 | 1226801-23-5 | 517.52 | 25 MG
AKT-IN-23 is an AKT inhibitor primarily used in cancer research. This compound is known for its specific targeting capabilities.
- Acts as an AKT inhibitor
- Suitable for cancer research applications
- Targets Akt
- Involves the PI3K/Akt/mTOR pathway
Medchemexpress LLC 1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one | 149732-52-5 | 292.33 | 1 MG
This product is 1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one, a potent nucleocapsid (N) protein inhibitor derived from *Curcuma kwangsiensis*. It demonstrates significant antiviral activity, particularly against HCoV-OC43 and SARS-CoV-2.
- Potent nucleocapsid protein inhibitor
- Isolated from *Curcuma kwangsiensis*
- Exhibits excellent antiviral activity against HCoV-OC43
- Shows strong antiviral activity against SARS-CoV-2
- Ideal for antiviral research and related applications
Medchemexpress LLC L-Cysteine, L-γ-glutamyl-S-1-propen-1-yl- | 91216-96-5 | 99.3% | 290.34 | 25 MG
γ-Glutamyl-S-1-propenyl cysteine is a compound isolated from garlic.
- Appearance: Solid
- Color: White to off-white
- Initial source: Plants, Liliaceae, Allium sativum Linn.
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage: -20°C, stored under nitrogen. In solvent: -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Medchemexpress LLC Naringenin | 480-41-1 | MFCD00006844 | 272.25 | 100 MG
Naringenin, a predominant flavanone found in Citrus reticulata Blanco, exhibits strong anti-inflammatory and antioxidant activities. It also demonstrates anti-dengue virus (DENV) activity. Research indicates Naringenin can inhibit proliferation of HepG2 cells by inducing G0/G1 and G2/M phase accumulation and apoptosis. It also reduces viability of A431 cells and has shown potential to reduce plasma and liver triglycerides, cholesterol, and adiposity.
- Displays strong anti-inflammatory and antioxidant activities.
- Exhibits anti-dengue virus (DENV) activity.
- Inhibits HepG2 cell proliferation.
- Induces G0/G1 and G2/M phase accumulation.
- Reduces A431 cell viability.
- Reduces plasma and liver triglycerides and cholesterol.
- Increases hepatic PPARα protein expression.
- Inhibits TNF-α-induced VSMC proliferation.
Medchemexpress LLC Chalcone dibromide | 611-91-6 | MFCD00017861 | 95.0% | 368.06 g·mol⁻1 | C15H12Br2O | 1 ML
Chalcone dibromide (CAS 611-91-6) is a dibrominated chalcone derivative supplied as a ready-to-use 10 mM solution in DMSO for research and synthetic applications. It is used as a synthon in the synthesis of bioactive heterocycles and has reported antioxidant and anticancer-related activity; product documentation includes datasheet, COA, and SDS.
- Supplied as a 10 mM solution in DMSO (1 mL).
- Molecular formula C15H12Br2O and molecular weight 368.06 g·mol⁻1.
- Purity 95.0%.
- Useful synthon for synthesis of pyrazolines, hydroxy pyrazolines, and isoxazoles.
- Available as a solid (100 mg) and larger sizes by quote.
- Documentation includes datasheet, certificate of analysis, and safety data sheet.
Medchemexpress LLC Dibenzoylmethane | 120-46-7 | MFCD00003085 | 98.0% | 224.26 | 25 G
Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. It is an analog of curcumin and results in dissociation from Keap1 and nuclear translocation of Nrf2. It is for research use only and not sold to patients.
- Activates Nrf2.
- Helps prevent various cancers and oxidative damage.
- Functions as an analog of curcumin.
- Leads to dissociation of Keap1 and nuclear translocation of Nrf2.
- Available in solid form, off-white to light yellow in color.
- Suitable for in vitro and in vivo studies.
- Stable for 3 years when stored as a solid at room temperature.
eMolecules 110231-30-6 | Diphenyl-1-pyrenylphosphine | ChemScene | MFCD00278755 | 386.434 | C28H19P | 95.000 | c1ccc(cc1)P(c1ccccc1)c1ccc2ccc3cccc4ccc1c2c34 | 1g | 582644065
Diphenyl-1-pyrenylphosphine | ChemScene | 110231-30-6 | MFCD00278755 | 386.434 | C28H19P | 95.000 | c1ccc(cc1)P(c1ccccc1)c1ccc2ccc3cccc4ccc1c2c34 | 1g | 582644065
Medchemexpress LLC PI3K/AKT-IN-1 | 3033069-84-7 | 99.6% | C23H23N5O4S | 25 MG
PI3K/AKT-IN-1 is an effective dual inhibitor of PI3K and AKT, exhibiting anticancer activity by inhibiting the PI3K/AKT axis and inducing caspase 3-dependent apoptosis. This compound has high cytotoxic activity against leukemia K562 and breast cancer MCF-7 cell lines, and is intended for research use only.
- Demonstrates high cytotoxic activity, particularly against leukemia cell line K562 (IC50=2.62 μM) and breast cancer cell line MCF-7 (IC50=3.22 μM)
- Promotes S-phase cell cycle arrest and induces apoptosis in K562 cells
- Significantly reduces the expression of PI3K, p-PI3K, AKT, p-AKT, Cyclin D1, and NF-κB
- Found to be non-toxic and well-tolerated in animal studies, with an LD50 greater than 2000 mg/kg
- Soluble in DMSO at 50 mg/mL
- Solid, off-white to light yellow appearance
Medchemexpress LLC Dibenzoylmethane | 120-46-7 | 98.0% | 224.26 | 1 G
Dibenzoylmethane is a minor ingredient found in licorice that functions as a Keap1-Nrf2 activator. It is known to prevent various cancers and oxidative damage. As an analog of curcumin, it facilitates dissociation from Keap1, leading to the nuclear translocation of Nrf2.
- Activates Nrf2
- Prevents various cancers and oxidative damage
- Increases mRNA level of HO-1 in HepG2 cells
- Induces HO-1 and Nrf2 protein expression
- Increases phosphorylated protein levels of Erk1/2, p38MAPK, JNK, AMPK, and Akt in HepG2 cells
- Reduces area and severity of necrosis and leukocyte infiltration
- Protects against CCl4-induced liver damage